%0 Journal Article
%T Relationship between Interleukin-10 ˋ1082A/G Polymorphism and Risk of Ischemic Stroke: A Meta-Analysis
%A Jun Jin
%A Wuying Li
%A Lingmei Peng
%A Jian Chen
%A Rong Li
%A Peihua Wu
%A Sheng Tan
%J PLOS ONE
%D 2014
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0094631
%X Objective To analyze the association between ˋ1082A/G polymorphism in interleukin-10 (IL-10) gene and ischemic stroke (IS) risk by meta-analysis. Methods We carried out a systematic electronic search in PubMed, BIOSIS Previews, Science Direct, Chinese National Knowledge Infrastructure, Chinese Biomedical Database, Weipu database and WANGFANG Database. Pooled odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated to assess the strength of the association. Results 7 studies were included. There was no significant association between IL-10 ˋ1082A/G polymorphism and IS risk under all genetic models in overall estimates (A vs. G: OR = 1.23,95%CI = 0.85每1.79;AA vs. GG: OR = 1.01,95%CI = 0.47每2.19; AG vs. GG: OR = 0.76, 95%CI = 0.38每1.55; AA+AG vs. GG: OR = 0.89,95%CI = 0.46每1.73; AA vs. AG+GG: OR = 1.39, 95%CI = 0.91每2.13). Similarly, no associations were found in subgroup analysis based on ethnicity and source of controls. However, removing the study deviating from Hardy每Weinberg equilibrium (HWE) produced statistically significant associations for overall estimates under recessive model(AA VS. AG+GG OR 1.58, 95% CI 1.04每2.42) and among Asians in all genetic models (A VS.G OR 1.64, 95% CI 1.07每2.53; AA vs. GG OR1.91, 95% CI 1.31每2.80; AG vs. GG OR1.44, 95% CI 1.09每1.91; AA+AG vs. GG OR 1.54, 95% CI 1.18每2.01;AA VS. AG+GG OR 1.79, 95% CI 1.07每3.00). Even after Bonferroni correction, the associations were observed still significantly in Asians under the two models (AA vs. GG OR1.91, 95% CI 1.31每2.80, P = 0.0008; AA+AG vs. GG OR 1.54, 95% CI 1.18每2.01, P = 0.001). Conclusion This meta-analysis indicates that IL10 ˋ1082 A/G polymorphism is associated with IS susceptibility in Asians and the ˋ1082 A allele may increase risk of IS in Asians. Considering the sample size is small and between-study heterogeneity is remarkable, more studies with subtle design are warranted in future.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0094631