%0 Journal Article
%T Imaging the Atherosclerosis with 64-Detector Row Computed Tomography in Homozygous Familial Hypercholesterolemia
%A Cihan Akgul Ozmen
%A Deniz Gokalp
%A Hasan Nazaroglu
%A Ayfer Gozu Pirinccioglu
%J Advances in Computed Tomography
%P 96-101
%@ 2169-2483
%D 2013
%I Scientific Research Publishing
%R 10.4236/act.2013.23017
%X <p class=\"MsoNormal\">
	<b><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:12px;\">Objective:</span></b><span lang=\"EN-US\"><span style=\"font-family:Verdana;font-size:12px;\"> The higher risk and fatality of cardiovascular disease in subjects
with homozygous familial hypercholesterolemia warrants early screening.
Computed tomography angiography is the most promising method at present as a
reliable and reproducible noninvasive diagnostic test of cardiovascular
disease. We aimed to describe the 64-slice multidetector computed tomography
coronary angiography findings of new cases with homozygous familial hypercholesterolemia. </span><b><span style=\"font-family:Verdana;font-size:12px;\">Methods:</span></b><span style=\"font-family:Verdana;font-size:12px;\"> Four patients with
homozygous familial hypercholesterolemia (2 female and 2 male) with mean age of
23</span></span><span lang=\"EN-US\"> </span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:12px;\">¡À</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:12px;\">9 years were included. Mean plasma total and LDL cholesterol were
654</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:12px;\">¡À</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:12px;\">75 mg/dl and 609</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:12px;\">¡À</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\"><span style=\"font-family:Verdana;font-size:12px;\">76 mg/dl. Tomography examinations were
performed using a 64-row MDCT-CA system (Brilliance Computed Tomography
scanner, Philips Healthcare). </span><b><span style=\"font-family:Verdana;font-size:12px;\">Results: </span></b><span style=\"font-family:Verdana;font-size:12px;\">All
patients presented calcified and mixed atherosclerotic plaques in the ascending
aorta near the origin of the coronary arteries. More extensive atherosclerosis
was found in Case 1 and Case 2 than in other cases. Case 3 has mild
atherosclerosis and Case 4 had normal coronaries but plaques in aorta. In
addition</span></span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:12px;\">,</span><span lang=\"EN-US\"><span style=\"font-family:Verdana;font-size:12px;\"> we detected myocardial bridging in left anterior descending artery
of 2 cases, calcified plaques in postero-lateral branch artery, and
calcification in non-coronary sinus in others.</span><b><span style=\"font-family:Verdana;font-size:12px;\">
%K Familial Hyperlipidemia
%K Cardiovascular Disease
%K Computed Tomography Angiography
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=37278