%0 Journal Article
%T Synthesis and Evaluation of Glyceride Prodrugs of Naproxen
%A Vivekkumar K. Redasani
%A Sanjay B. Bari
%J Open Journal of Medicinal Chemistry
%P 87-92
%@ 2164-313X
%D 2013
%I Scientific Research Publishing
%R 10.4236/ojmc.2013.33011
%X <p class=\"MsoNormal\">
	<span lang=\"EN-US\"><span style=\"font-family:Verdana;font-size:10px;\">The glyceride ester derivatives </span><st1:chmetcnv tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"False\" sourcevalue=\"6\" unitname=\"a\" w:st=\"on\"><b><span style=\"font-family:Verdana;font-size:10px;\">6a</span></b></st1:chmetcnv><span style=\"font-family:Verdana;font-size:10px;\"> and </span><b><span style=\"font-family:Verdana;font-size:10px;\">6b</span></b><span style=\"font-family:Verdana;font-size:10px;\"> were prepared by reacting </span><span style=\"font-family:Verdana;font-size:10px;\">1,2,3-trihydroxy
propane 1,3-dipalmitate/stearate with (S)-naproxen as potential
prodrugs. The synthesis was achieved successfully with the aid of </span><span style=\"font-family:Verdana;font-size:10px;\">N,N</span></span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:10px;\">กฏ-</span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:10px;\">dicyclohexyl</span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:10px;\">- </span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:10px;\">carbodiimide</span><span lang=\"EN-US\"><span style=\"font-family:Verdana;font-size:10px;\">.
These prodrugs were evaluated for anti inflammatory, analgesic and gastroprotective
activity. It was found that prodrugs </span><st1:chmetcnv tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"False\" sourcevalue=\"6\" unitname=\"a\" w:st=\"on\"><b><span style=\"font-family:Verdana;font-size:10px;\">6a</span></b></st1:chmetcnv><span style=\"font-family:Verdana;font-size:10px;\"> and </span><b><span style=\"font-family:Verdana;font-size:10px;\">6b</span></b><span style=\"font-family:Verdana;font-size:10px;\"> show</span></span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:10px;\">ed</span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:10px;\"> less irritation
to gastric mucosa as indicated by ulcer index. The synthesized glyceride esters </span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:10px;\">were </span><span lang=\"EN-US\"><span style=\"font-family:Verdana;font-size:10px;\">found to possess good pharmacological profile as shown by results of
anti inflammatory and analgesic activity. The aqueous studies were performed in
order to ensure the release of prodrugs. Both prodrugs were found to stable at
acidic pH while undergoes hydrolysis at pH 7.4. These findings suggest that the
glyceride prodrugs </span><st1:chmetcnv tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"False\"
%K Naproxen
%K Glyceride Prodrugs
%K Anti-Inflammatory
%K Analgesic
%K Gastroprotective
%K Hydrolysis Kinetics
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=37080