%0 Journal Article %T 6-Azido-Galactosyl Imidate as a Building Block for Preparation of 1-(4-Aminobutyl)-, Di-, Tri- and Tetra-Saccharides %A Kun-I Lin %A Li-Wu Chiang %A Cheng-Tse Pan %A Ho-Lien Huang %A Yuan-Hsiao Su %A Shui-Tein Chen %A Ying-Cheng Huang %A Chung-Shan Yu %J Open Journal of Medicinal Chemistry %P 74-86 %@ 2164-313X %D 2013 %I Scientific Research Publishing %R 10.4236/ojmc.2013.33010 %X

6-azidogalactosyl imidate has been used as a donor to generate 1-(4-aminobutyl)-6-aminogalactose, 6-aminothiotolyl- glycosides of disaccharide, trisaccharide and tetrasaccharide that incorporates 6-azido group and 1-(4-tolyl)thio group. Trisaccharide and tetrasaccharide were obtained from lactosyl-based acceptor. The anomeric 1-(4-tolyl)thio group could be used to conjugate with sphingosine analogs to provide the alpha-Gal Sph analogs for library extension from the azido group.

%K Glycosylation %K Chemoselective %K Imidate %K Building Block %K Lactoside %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=37079