%0 Journal Article
%T Addition of Metanx in pregabalin partial  responders for painful diabetic neuropathy
%A Allen Mark Jacobs
%A Dunlei Cheng
%J Journal of Diabetes Mellitus
%P 134-138
%@ 2160-5858
%D 2013
%I Scientific Research Publishing
%R 10.4236/jdm.2013.33020
%X <p style=\"text-align:justify;\">
	<span style=\"font-size:10.0pt;font-family:;\" \"=\"\"><span style=\"font-family:Verdana;font-size:12px;\">Objective: To study the effect of addition of Metanx</span><span style=\"font-family:Verdana;font-size:12px;\">&nbsp;on burning parasthesias in patients with symptomatic diabetic neuropathy who
had obtained only partial symptom resolution with pregabalin. Research design
and methods: This was an open-label pilot study. There were 16 patients (7
males, 9 females) in the study group and 8 patients (3 males, 5 females) in the
control group. A patient numeric rating scale (0 - 10) of neuropathy
associated pain was obtained at </span><span style=\"font-family:Verdana;font-size:12px;\">baseline and
at 20 weeks. The control group con</span><span style=\"font-family:Verdana;font-size:12px;\">tinued on a fixed dosage of
pregabalin (Lyrica</span><span style=\"font-family:Verdana;font-size:12px;\">) without additional medication, while the study
group was supplemented with Metanx</span><span style=\"font-family:Verdana;font-size:12px;\">&nbsp;(L-methylfolate,
methylcobalamin, and pyridoxal 5- phosphate), in addition to being continued on
a fixed dosage of pregabalin. Results: After 20 weeks, patients in the study group
experienced greater pain relief compared to the control group, (87.5% vs. 25%
respectively, p = 0.005). The average pain score reduction after 20 weeks in
the study group was 3 compared to0.25
 inthe control group (p &lt; 0.001). Conclusion: Our study suggested
that addition of Metanx</span><span style=\"font-family:Verdana;font-size:12px;\">&nbsp;may be used for the relief of pain in
patients that have obtained only partial resolution of symptomatology from
pregabalin. </span></span> 
</p>
%K L-Methylfolate
%K Methylcobalamin
%K Metanx
%K Diabetic Neuropathy
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=35011