%0 Journal Article
%T Protective Effects of Many <i>Citrus</i> Flavonoids on Cartilage Degradation Process
%A Lucia Crasc¨¬
%A Annamaria Panico
%J Journal of Biomaterials and Nanobiotechnology
%P 279-283
%@ 2158-7043
%D 2013
%I Scientific Research Publishing
%R 10.4236/jbnb.2013.43035
%X <span><span style=\"font-family:Verdana;\">The objective of this study was to investigate the effects of many </span><i><span style=\"font-family:Verdana;\">citrus </span></i><span style=\"font-family:Verdana;\">flavanones, such as neoeriocitrin, naringin and neohesperidin, in cartilage degradation. Degenerative joint disease involved degradation of joints, including articular cartilage and subchondral bone. When bone surfaces become less well protected by cartilage, bone may be exposed and damaged. The degradation cartilage is mediated by alteration of the balance between anabolic and catabolic processes, changes in proteolytic enzyme activity, mechanical disruption of the cartilage extracellular matrix (ECM), or a com</span></span><span style=\"font-family:Verdana;\">bination of these processes. We examine the capability of neoeriocitrin, naringin and neohesperidin, to inhibit metallo</span><span style=\"font-family:Verdana;\">proteinase (MMP)-13, collagenase involved in degradation of cartilage matrix components. Also, we assay the flavon</span><span style=\"font-family:Verdana;\">oids effect on reducing of Glycosaminoglycans (GAGs) release, and restore Nitric oxide (NO) levels in explant of hu</span><span style=\"font-family:Verdana;\">man articular cartilage. Our results suggest that neoeriocitrin, naringin and neohesperidin are a potential therapeutic agent to protect cartilage tissue.</span>
%K Neoeriocitrin
%K Naringin
%K Neohesperidin
%K Metalloproteinases-13
%K Cartilage Degradation
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=34773