%0 Journal Article
%T Motor Effects of 1,3-Disubstituted 8-Styrylxanthines as A<sub>1</sub> and A<sub>2</sub> Adenosine-Receptor Antagonists in Rats
%A Ilhuicamina Daniel Lim¨®n-P¨¦rez de Le¨®n
%A Mar¨ªa del Carmen Parra-Cid
%A Alejandro Mu£¿oz-Zurita
%A Sa¨²l Alejandro Merino-Contreras
%A Sara Montiel-Smith
%A Socorro Meza-Reyes
%A Gerardo Ram¨ªrez-Mej¨ªa
%A Jes¨²s Sandoval-Ram¨ªrez
%J Pharmacology & Pharmacy
%P 303-311
%@ 2157-9431
%D 2013
%I Scientific Research Publishing
%R 10.4236/pp.2013.43044
%X <p class=\"MsoNormal\">
	<span style=\"font-family:Verdana;\">A series of 1,3-substituted 8-styrylxanthines (</span><span style=\"font-family:Verdana;\">11a-d</span><span style=\"font-family:Verdana;\">) was synthesized, under chemo-
and regioselective conditions, in a good overall yield. The compounds showed
affinity towards both A</span><span style=\"font-family:Verdana;\"><sub>1</sub></span><span style=\"font-family:Verdana;\"> and A</span><span style=\"font-family:Verdana;\"><sub>2A</sub></span><span style=\"font-family:Verdana;\">-adenosine receptors by
radioligand binding by means of</span><span style=\"font-family:Verdana;\"> in vitro</span><span style=\"font-family:Verdana;\"> assays. The (</span><span style=\"font-family:Verdana;\">E</span><span style=\"font-family:Verdana;\">)-3-ethyl-1-propyl-8-styrylxanthine
(</span><span style=\"font-family:Verdana;\">11a</span><span style=\"font-family:Verdana;\">) showed the greatest
affinity towards the A</span><span style=\"font-family:Verdana;\"><sub>2A</sub></span><span style=\"font-family:Verdana;\"><sub> </sub>receptor, whereas (</span><span style=\"font-family:Verdana;\">E</span><span style=\"font-family:Verdana;\">)-3-pentyl-1-propyl-8-styrylxanthine (</span><span style=\"font-family:Verdana;\">11d</span><span style=\"font-family:Verdana;\">) showed the
greatest affinity for the A</span><span style=\"font-family:Verdana;\"><sub>1</sub></span><span style=\"font-family:Verdana;\"> receptor. When the 8-styrylxanthines </span><span style=\"font-family:Verdana;\">11a (A15Et)</span><span style=\"font-family:Verdana;\"> and </span><span style=\"font-family:Verdana;\">11c (A15Bu) </span><span style=\"font-family:Verdana;\">were administrated in rats, which were previously
injured with 6-hydroxydopamine at the </span><span style=\"font-family:Verdana;\">su</span><span style=\"font-family:Verdana;\">bstantia nigra pars</span> <span style=\"font-family:Verdana;\">compacta </span><span style=\"font-family:Verdana;\">(SNc), the turning behavior decreased 50%. Based on these results we propose to A15Et as a
potential compound to treat some symptoms of Parkinson¡¯s disease.</span> 
</p>
%K Xantines
%K Adenosine Receptors Antagonists
%K Turning Behavior
%K Anti-Parkinsonian Drugs
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=32557