%0 Journal Article
%T Clinical Study on Autosomal Dominant Polycystic Kidney Disease among South Indians
%A P. Veeramuthumari
%A W. Isabel
%J International Journal of Clinical Medicine
%P 200-204
%@ 2158-2882
%D 2013
%I Scientific Research Publishing
%R 10.4236/ijcm.2013.44035
%X <p class=\"MsoNormal\" style=\"text-align:justify;\">
	<span lang=\"EN-US\">Autosomal</span><span lang=\"EN-US\"> </span><span lang=\"EN-SG\">dominant</span><span lang=\"EN-US\"> polycystic kidney disease (ADPKD) is
a commonly inherited disorder in humans, with a fre</span><span lang=\"EN-US\">quency of 1 in 100 in the general
population. ADPKD is caused by mutations in PKD1 gene (85%) located on human
chromosome 16p13.3; Mutations in the PKD2 gene contribute to 15% of ADPKD
incidence and is located on human chromosome 4q2</span><span lang=\"EN-US\">-</span><span lang=\"EN-US\">23. A total of hundred ADPKD patients
and age and sex matched healthy individuals were selected for the study. The
study was aimed to evaluate the prevalence of ADPKD, lipid profile and level of
calcium (Ca), so</span><span lang=\"EN-US\">dium
(Na), iron (Fe) and potassium (K) in patients with ADPKD and in healthy individuals.
The lipid profile was ana</span><span lang=\"EN-US\">lyzed using commercially available span kit and semiautoanalyzer </span><span lang=\"EN-SG\">(Erba, Chem 5X). </span><span lang=\"EN-US\">The
Ca, Na, Fe and K concentra</span><span lang=\"EN-US\">tions were estimated by flame photometry (</span><span lang=\"EN-SG\">ELICO,
CL 22D)</span><span lang=\"EN-SG\"> </span><span lang=\"EN-US\">and atomic absorption spectroscopy </span><span lang=\"EN-SG\">(ELICO, SL 173)</span><span lang=\"EN-US\"> and
significant changes were noted at p</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\">&lt;</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\">0.05. The ADPKD
patients were observed to have lipid abnormalities, hypona</span><span lang=\"EN-US\">tremia, cholesterolemia, renal
osteodystrophy, cardiovascular problems and anemia. Therefore, the study
reveals an as</span><span lang=\"EN-US\">sociation
between the lipid profile and Ca, Na, Fe and K levels with ADPKD among South
Indian population.</span> 
</p>
%K Polycystic Kidney Disease
%K Hyponatremia
%K Renal Osteodystrophy
%K Anemia
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=30882