%0 Journal Article
%T Immune system as a new therapeutic target for antibiotics
%A Brygida Kwiatkowska
%A Maria Maslinska
%A Malgorzata Przygodzka
%A Joanna Dmowska-Chalaba
%A Justyna Dabrowska
%A Katarzyna Sikorska-Siudek
%J Advances in Bioscience and Biotechnology
%P 91-101
%@ 2156-8502
%D 2013
%I Scientific Research Publishing
%R 10.4236/abb.2013.44A013
%X <p>
	<span style=\"font-size:10.0pt;\"><span style=\"font-family:Verdana;font-size:12px;\">Since the discovery of
penicillin by Fleming in 1928, </span><span style=\"font-family:Verdana;font-size:12px;\">the knowledge
of the antibiotics¡¯ spectrum and</span><span style=\"font-family:Verdana;font-size:12px;\"> mechanism of action has been steadily
increasing. Antibiotics became an effective tool in the fight against many
pathogens, changing the prognosis of outcome for many serious diseases. It is
already known that antibiotics not only have the antibacterial activity, but
many of them</span></span><span style=\"font-size:12px;font-family:Verdana;\">¡ª</span><span style=\"font-size:10.0pt;\"><span style=\"font-family:Verdana;font-size:12px;\">e.g.
macrolides, sulphonamides and tet</span><span style=\"font-family:Verdana;font-size:12px;\">racyclines</span></span><span style=\"font-size:12px;font-family:Verdana;\">¡ª</span><span style=\"font-size:12px;font-family:Verdana;\">have immunomodulating effect, affec</span><span style=\"font-size:10.0pt;\"><span style=\"font-family:Verdana;font-size:12px;\">ting functions of lymphocytes, macrophages and costim</span><span style=\"font-family:Verdana;font-size:12px;\">ulatory molecules, macrophage migration and pha</span><span style=\"font-family:Verdana;font-size:12px;\">gocytosis,
as well as proinflammatory cytokine secretion. The expanding knowledge of the
effects of antibiotics on the immune system has brought with it new
applications of antibiotics in organ transplantation, invasive cardiology and
treatment of autoim</span><span style=\"font-family:Verdana;font-size:12px;\">mune diseases such as rheumatoid
arthritis or</span><span style=\"font-family:Verdana;font-size:12px;\"> asthma.</span></span> 
</p>
%K Immunomodulatory
%K Macrolides
%K Tetracyclines
%K Sulphonamides
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=30658