%0 Journal Article
%T Solid Phase Synthesis of 3,4,5-Trisubstituted-1,2,4-Triazoles  Derivatives from the Resin-Bound Acylhydrazines
%A Rongjian Xie
%A Xingang Liu
%A Chao Mai
%A Zhanxiang Liu
%J International Journal of Organic Chemistry
%P 35-40
%@ 2161-4695
%D 2013
%I Scientific Research Publishing
%R 10.4236/ijoc.2013.31A004
%X <p class=\"MsoNormal\">
	<span lang=\"EN-US\" style=\"font-family:Verdana;font-size:10px;\">An extension of our methodology on
solid-phase synthesis of 3,4,5-trisubstituted-1,2,4-triazoles under mild</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:10px;\">conditions has been developed. </span><span lang=\"EN-US\"><span style=\"font-size:10px;\">First</span><span style=\"font-size:10px;\">ly</span></span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:10px;\">, the resin-bound acylhydrazine is reacted with orthoesters to provide
resin-bound 1,3,4-oxadiazoles. Secondly, condensation of 1,3,4-oxadiazoles
resin with the corresponding arylamines hydrochloride to form the the
resin-bound triazoles. 3,4,5-Trisubstituted-1,2,4-triazoles derivatives were
obtained from resin-bound acylhydrazines in several steps providing 78</span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:10px;\">% - </span><span lang=\"EN-US\" style=\"font-family:Verdana;font-size:10px;\">87% overall yields and excellent
purity. The advantages of this method include straightforward operation and
high yield and purity of the products.</span> 
</p>
%K Resin-Bound Acylhydrazine
%K Solid-Phase Synthesis
%K 1
%K 2
%K 4-Triazoles
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=30716