%0 Journal Article
%T Synthesis, antimicrobial and antioxidant activities of 1-(1,4-benzodioxane-2-carbonyl)piperazine derivatives
%A Lingappa Mallesha
%A Kikkeri Narasimhasetty Mohana
%J European Journal of Chemistry
%D 2011
%I 
%R 10.5155/eurjchem.2.2.193-199.282
%X A series of novel 1-(1,4-benzodioxane-2-carbonyl)piperazine derivatives (6a-h) and (7a-e) were synthesized by nucleophilic substitution reaction of 1-(1,4-benzodioxane-2-carbonyl)piperazine (3) with various sulfonyl and acid chlorides. The newly synthesized compounds were characterized by elemental analyses, UV-visible, FT-IR, 1H NMR and LC-MS spectral studies. All compounds were evaluated for in vitro antibacterial, antifungal and antioxidant activities. Compound, 4-(2-trifluoromethyl)-benzenesulfonyl-1-(1,4-benzodioxane -2-carbonyl)piperazine (6b) exhibited significant antimicrobial activity against tested pathogenic bacterial and fungal strains. Compound, 4-(3-methoxy)-benzoyl-1-(1,4-benzodioxane-2-carbonyl)piperazine (7a) showed moderate antioxidant activity compared to standard drug by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay method.
%K 1-(1
%K 4-Benzodioxane-2-carbonyl)piperazine
%K Antimicrobial activity
%K Antioxidant activity
%K Structure-activity relationship
%K Sulphonyl chlorides
%K Acid chlorides
%U http://www.eurjchem.com/index.php/eurjchem/article/view/282