%0 Journal Article %T Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety %A Wafaa Ramzy Abdel-Monem %J European Journal of Chemistry %D 2010 %I %R 10.5155/eurjchem.1.3.168-172.29 %X 7-(4-Chloro/3-nitrophenyl)-8-[5,6-diphenyl-4-(1,3-thiazol-2-yl)-1,4-dihydro-1,2,4-triazin-3-yl]-5-oxo-1,5-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitrile (6a, b) was utilized as a key intermediate for the target polyheterocyclic systems. Reactions of 6a, b with halocarbonyl reagents followed by heterocyclization with bi-nitrogen nucleophiles gave some new nitrogen heterocycles (7-13). Structures of the new compounds were established by elemental analyses and spectral data. The synthesized compounds were screened for their antimicrobial activity. %K 1 %K 2 %K 4-Triazine %K 1 %K 2 %K 4-Triazole %K Imidazole %K Polyheterocyclic nitrogen systems %K Antimicrobial activity %U http://www.eurjchem.com/index.php/eurjchem/article/view/29