%0 Journal Article
%T DEVELOPMENT AND VALIDATION OF UV DERIVATIVE SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF GLIMEPIRIDE, METFORMINE HCL AND PIOGLITAZONE HCL IN BULK AND MARKETED FORMULATION
%A Patil Pallavi M
%A Rathod Sonali D
%A Chaudhari Praveen.D.
%J Journal of Pharmaceutical and Scientific Innovation
%D 2012
%I Moksha Publishing House
%X UV Derivative Spectrophotometric methods for the simultaneous determination of Glimepiride (GLM), Metformin HCL (MFN) and Pioglitazone HCL (PLZ) in tablets were developed in the present work. The various parameters, such as linearity, precision, accuracy, specificity, robustness, limit of detection and limit of quantitation were studied according to (ICH) International Conference on Harmonization guidelines.The first derivative UV spectrophotometric method was performed at 227nm, 233nm and 265.5nm for GLM, MET and PIO respectively in 0.1N NaOH solution and distilled water (50:50). The proposed methods are highly sensitive, precise and accurate and therefore can be used for its intended purpose.
%K Anti-diabetic drugs
%K Glimepiride
%K Metformin HCL and Pioglitazone HCL
%K Validation.
%U http://jpsionline.com/admin/php/uploads/75_pdf.pdf