%0 Journal Article
%T HISTOLOGICAL STUDIES OF THE EFFECTS OF MONOSODIUM GLUTAMATE ON THE SMALL INTESTINE OF ADULT WISTAR RATS
%A A.O.Eweka
%A F.A.E. Om'Iniabohs
%J Electronic Journal of Biomedicine
%D 2007
%I Asociaci¨Žn Red Uninet
%X The effects of monosodium glutamate (MSG) used as food additive on the small intestine of adult wistar rat was investigated. Both adult male and female Wistar rats (n=24) of average weight of 185g were randomly assigned into two treatments (n=16) and control (n=8) groups. The rats in the treatment groups received 3g and 6g of MSG thoroughly mixed with grower's mash daily for fourteen days. The control rats received equal amounts of grower's mash without MSG added daily. The grower's mash was obtained from Edo Feeds and Flour Mill Ltd, Ewu, Edo State and the rats were given water ad libitum. The rats were sacrificed on day fifteen of the experiment. The small intestine was carefully dissected out and quickly fixed in 10% formal saline for routine histological procedures.The histological findings in the treated groups showed evidence of increased basophilia and cellular hypertrophy in animals given 3g of MSG, while degenerative and atrophic changes in the group with 6g of MSG was more pronounced. These findings indicate that Monosodium glutamate may have some deleterious effects on the microanatomy of the small intestine of adult Wistar rats at higher doses. It is recommended that further studies aimed at corroborating these findings be carried out
%K Monosodium glutamate
%K Histological effect
%K Small intestine
%K Wistar rats
%U http://biomed.uninet.edu/2007/n2/eweka-i.html