%0 Journal Article
%T Expression of p53, p16 and Ki67 proteins in ductal adenocarcinoma of the pancreatic head and their relation with survival and cell differentiation
%A M¨¢rio Benjamin Goitia-Dur¨¢n
%A Marcelo Moura Linhares
%A Ricardo Artigiani Neto
%A Franz Robert Apodaca-Torrez
%J Einstein (S£¿o Paulo)
%D 2010
%I Instituto Israelita de Ensino e Pesquisa Albert Einstein
%X Objective: To determine the expression of p53, p16 and Ki-67 and its relevance in survival and cell differentiation. Methods: Fifteen duodenopancreatectomized patients were included. Immunohistochemical expression of p53, p16 and Ki-67 was determined in paraffin embedded tumor blocks. The relation of these expressions with different variables was studied. Results: Ninety-three per cent of tumors showed expression of p53 and p16. Ki-67 was expressed in 86.66% of tumors (labeling index ¨C LI 11.91 ¡À 9.47). The presence of combined alterations was not related to significant differences in tumor type, stage or survival; similar results were obtained analyzing isolated expressions. When groups of p16 and Ki-67 expressions where created, the median survival was not significant. However, there was a slightly better survival in patients with focal expression of p16 (median survival 20.75 versus 14.34), when compared to patients with diffuse expression. Conclusion: The overexpression of p53, p16 and Ki-67 was not related to survival or tumor grade, when comparing isolated or combined expressions.
%K Tumor suppressor proteins/analysis
%K Cell cycle proteins/analysis
%K Ki-67 antigen/analysis
%K Tumor suppressor protein p53
%K Pancreatic neoplasms
%K Survivorship
%U http://apps.einstein.br/revista/arquivos/PDF/1655-Einsteinv8n4_pg444-448_eng.pdf