%0 Journal Article %T Antioxidants deficiency: a sensitive indicator of cardiometabolic risk in chronic renal failure? %A Pooja S.K. Rai %A Sangita Kamath %A Amruta A. Bakshi %A Smita A. Deokar %J International Journal of Research in Medical Sciences %D 2013 %I Medip Academy %R 10.5455/2320-6012.ijrms20130510 %X Background: Antioxidant depletion occurring in chronic renal failure patients is an important cause of associated morbidity & mortality, which in turn imposes a great socioeconomic burden of health care. Early diagnosis & targeted management of this preventable deficiency may have a positive impact on the management of co morbidities associated with chronic renal failure. Aims & Objectives: To evaluate the status of antioxidants as an early indicator of cardiometabolic risk in chronic renal failure patients. Settings & Design: This was a randomised case Control study including 10 controls of either sex with normal renal function between age group 20-60 years and 15 patients of chronic renal failure on dialysis between the age group of 16 - 60 years. Methods: 12 hour fasting venous blood samples were collected from all the participants and were assayed for various antioxidants. Statistical analysis: Results were analyzed by unpaired t test, p value was determined & Correlation coefficient was calculated amongst various parameters. Results: In the present study, significantly low levels of vitamin C ( Cases: 0.367 ¡À 0.13 mg/dl controls: 1.324 ¡À 0.61 mg/dl; p < 0.01) & vitamin E (cases: 0.235 ¡À 0.102 mg/dl, controls (0.854 ¡À 0.28 mg/dl; p < 0.01) were observed in chronic renal failure patients as compared to controls. Conclusion: Diminished levels of Vitamin C & E in our study may be an indicator of increased oxidative stress which can be a responsible factor for increased incidence of cardiovascular complications. Supplementing these patients with recommended dosage of these vitamins may provide an essential tool to reduce the burden of suffering. [Int J Res Med Sci 2013; 1(2.000): 87-92] %K Chronic renal failure (CRF) %K Antioxidants %K Vitamin C %K Vitamin E %U http://www.scopemed.org/fulltextpdf.php?mno=34588