%0 Journal Article
%T Flavonoid from Intsia palembanica as Skin Whitening Agent
%A I. Batubara
%A L.K. Darusman
%A T. Mitsunaga
%A H. Aoki
%J Journal of Biological Sciences
%D 2011
%I Asian Network for Scientific Information
%X This study aims to obtain active compounds from Intsia palembanica with skin whitening activity. I. palembanica methanol extracts were separated using chromatography techniques and yielded 3 flavanols. Isolated compounds along with 6 other flavonoid compounds were analyzed for tyrosinase inhibitory activity and inhibition of melanin cell growth in B16 cell. The results showed that (-)-robidanol is the most potent tyrosinase inhibitor (IC50 monophenolase 8.7 M; diphenolase 26.6 M) and inhibit melanin synthesis 46.2% compared to control (at 100 M). In conclusion, (-)-robidanol is the best compound as a whitening agent.
%K whitening agent
%K Instia palembanica
%K (-)-robidanol
%K tyrosinase inhibitor
%K melanin
%U http://docsdrive.com/pdfs/ansinet/jbs/2011/475-480.pdf