%0 Journal Article %T Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats %A In Hee Kim1 %A 2 %A Dae-Ghon Kim1 %A 2* %A Peipei Hao2 %A Yunpeng Wang2 %A Seong Hun Kim1 %A 2 %A Sang Wook Kim1 %A 2 %A Seung Ok Lee1 %A 2 & Soo Teik Lee1 %A 2 %J BMB Reports %D 2012 %I Korean Society for Biochemistry and Molecular Biology %X L-2-Oxothiazolidine-4-carboxylic acid (OTC) is a cysteine prodrugthat maintains glutathione in tissues. The present studywas designed to investigate anti-fibrotic and anti-oxidative effectsof OTC via modulation of nuclear factor erythroid 2-relatedfactor 2 (Nrf2) in an in vivo thioacetamide (TAA)-inducedhepatic fibrosis model. Treatment with OTC (80 or 160 mg/kg)improved serum liver function parameters and significantlyameliorated liver fibrosis. The OTC treatment groups exhibitedsignificantly lower expression of ¦Á-smooth muscle actin, transforminggrowth factor-¦Â1, and collagen ¦Á1 mRNA than that inthe TAA model group. Furthermore, the OTC treatment groupsshowed a significant decrease in hepatic malondialdehyde levelcompared to that in the TAA model group. Nrf2 and hemeoxygenase-1 expression increased significantly in the OTCtreatment groups compared with that in the TAA model group.Taken together, these results suggest that OTC restores the anti-oxidative system by upregulating Nrf2; thus, ameliorating liverinjury and a fibrotic reaction. %K L-2-Oxothiazolidine-4-carboxylic acid %K Liver fibrosis %K Nrf2 %K Oxidative stress %K Thioacetamide %U http://www.jbmb.or.kr/jbmb/pdf.php?data=MTMwMTIyMTdAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS02JTVEMTIwNjI2MDcxM18lMjgzNDgtMzUzJTI5Qk1CXzExLTI3Ni5wZGY=