%0 Journal Article
%T Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein
%A Sun Hwa Lee1
%A #
%A Dae Won Kim1
%A #
%A Seon Ae Eom1
%A Se-Young Jun1
%A Meeyoung Park1
%A Duk-Soo Kim2
%A Hyung Joo Kwon3
%A Hyeok Yil Kwon4
%A Kyu Hyung Han1
%A Jinseu Park1
%A Hyun Sook Hwang1
%A Won Sik Eum1
%A * & Soo Young Choi1
%A *
%J BMB Reports
%D 2012
%I Korean Society for Biochemistry and Molecular Biology
%X We examined that the protective effects of ANX1 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammationin animal models using a Tat-ANX1 protein. Topicalapplication of the Tat-ANX1 protein markedly inhibited TPAinducedear edema and expression levels of cyclooxygenase-2(COX-2) as well as pro-inflammatory cytokines such as interleukin-1 beta (IL-1¦Â), IL-6, and tumor necrosis factor-alpha(TNF-¦Á). Also, application of Tat-ANX1 protein significantlyinhibited nuclear translocation of nuclear factor-kappa B(NF-¦ÊB) and phosphorylation of p38 and extracellular signalregulatedkinase (ERK) mitogen-activated protein kinase(MAPK) in TPA-treated mice ears. The results indicate thatTat-ANX1 protein inhibits the inflammatory response byblocking NF-¦ÊB and MAPK activation in TPA-induced miceears. Therefore, the Tat-ANX1 protein may be useful as atherapeutic agent against inflammatory skin diseases.
%K Cytokine
%K Inflammation
%K MAPK
%K Tat-ANX1
%K TPA
%U http://www.jbmb.or.kr/jbmb/pdf.php?data=MTMwMTIyMTdAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS02JTVEMTIwNjI2MDcxNl8lMjgzNTQtMDU5JTI5Qk1CXzEyLTAzNi5wZGY=