%0 Journal Article
%T Differential expression of cell surface markers in response to 2,4-dinitrofluorobenzene in RAW 264.7 and primary immune cells
%A Dongbum Kim1
%A Min Chul Park1
%A Byoung Kwon Park1
%A Sanghoon Kwon2
%A Joon-Ho Choi3
%A Hyun-Jong Kim4
%A Soo-Young Choi5
%A Jinseu Park5
%A Younghee Lee6 & Hyung-Joo Kwon1
%A 2
%A *
%J BMB Reports
%D 2012
%I Korean Society for Biochemistry and Molecular Biology
%X We evaluated the expression of the costimulatory moleculesCD80 and CD83 and major histocompatibility (MHC) class IIinduced by 2,4-dinitrofluorobenzene (DNFB) in the RAW264.7 macrophage cell line. In contrast to the previously reportedeffect of DNFB on dendritic cells, CD86 expression didnot change. Furthermore, we observed that the CD83 expressionlevel transiently increased and then decreased.Induction of CD80 and MHC class II molecule expression anda decrease in CD83 expression by DNFB in vitro were alsoconfirmed in splenocytes of BALB/c and NC/Nga mice.However, DNFB did not influence CD83 expression in peritonealCD11b+ cells from BALB/c or NC/Nga mice. Detailedin vivo experiments and further studies on the possible contributionof CD11b+ cells to induce atopic dermatitis (AD)would be helpful to attain a better understanding of ADpathogenesis.
%K Atopic dermatitis
%K Costimulatory molecules
%K DNFB
%K Macrophages
%K NC/Nga mice
%U http://www.jbmb.or.kr/jbmb/pdf.php?data=MTMwMTIyMTdAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS05JTVEMTIwOTI3MTU0Ml8lMjg1MzgtNTQzJTI5Qk1CXzEyLTA0OC5wZGY=