%0 Journal Article
%T Anti-inflammatory effects of a methanol extract from Pulsatilla koreana in lipopolysaccharide-exposed rats
%A Sang Hyun Lee1
%A Eun Lee1
%A * & Young Tag Ko2
%A *
%J BMB Reports
%D 2012
%I Korean Society for Biochemistry and Molecular Biology
%X To investigate the therapeutic effect of a Korean herbal medicinePulsatilla koreana as an anti-septic agent, anti-inflammatoryeffects of the herbal medicine were determined in lipopolysaccharide(LPS)-exposed rats. Treatment with a methanol extractfrom Pulsatilla koreana significantly inhibited LPS-inducedinflammatory responses. Results from ELISA analysis showed thatPulsatilla koreana decreased the plasma and hepatic levels ofpro-inflammatory cytokines such as IL-1¦Â, IL-6, TNF-¦Á whileincreased the level of anti-inflammatory cytokine IL-10 inLPS-exposed rats. Pulsatilla koreana also decreased the plasmalevels of other inflammatory mediators such as NO3-/NO2-,ICAM-1, PGE2, and CINC-1 in LPS-exposed rats. Although nosignificant effects were observed in the phagocytic activities, thedistribution of lymphocyte population was significantly shiftedby the treatment with Pulsatilla koreana. All together, Pulsatillakoreana exerts anti-inflammatory activities in the immunechallengedanimals implicating that this Korean herbal medicineis therapeutically useful for the treatment of inflammatorydiseases like sepsis.
%K Anti-inflammation
%K Cytokines
%K Herbal medicine
%K Pulsatilla koreana
%K Sepsis
%U http://www.jbmb.or.kr/jbmb/pdf.php?data=MTMwMTIyMTdAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS02JTVEMTIwNjI2MDcyMV8lMjgzNzEtMzc2JTI5Qk1CXzEyLTAxOC5wZGY=