%0 Journal Article
%T SYNTHESIS AND DOCKING STUDIES OF 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDE DERIVATIVES
%A K. Hemalatha*
%A Nandakishore Agarwal and G. Buchappa
%J International Journal of Pharmaceutical Sciences and Research
%D 2013
%I Society of Pharmaceutical Sciences and Research
%X A novel N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-pipear azinyl]-2-methyl-4-pyrimidinyl] amino]-5-thiazolecarboxamide derivatives (6a-6d) and (8a-8b) were synthesized by coupling 2-[(6-chloro-2-methylpyrimidin-4ylamino]-N-(2-chloro-6-methylphenyl) thiazole-5-Carboxamide(3) with Piperazine derivatives(4,7) in butanol and DIPEA (Diisopropylethylamine) at 120oC for 4-5hrs. All the synthesized compounds were characterized physically and elucidated by Infrared spectroscopy, Mass spectroscopy, 1H-NMR spectroscopic techniques. All the synthesized compounds were subjected to Molecular docking studies by using 2GQG as its PDB ID. Among all the compounds, 6a, 6b, 6d, 8c and 8b exhibit anticancer activity.
%K 2-amino-thiazole-5-carboxamide derivatives
%K Piperazine derivatives
%K Docking and 2GQG
%K anti-cancer activity
%U http://ijpsr.com/V4I2/44%20Vol.%204,%20Issue%202,%20Feb%202013,%20IJPSR,%20RA-2126,%20Paper%2044.pdf