%0 Journal Article
%T Pharmacokinetics of Chloramphenicol Following Intravenous and Intramuscular Administration of the Drug to Healthy Sokoto Red Goats
%A E.U. Etuk
%A P.A. Onyeyili
%A B.Y. Muhammed
%J International Journal of Pharmacology
%D 2005
%I Asian Network for Scientific Information
%X Pharmacokinetics studies were performed in healthy red Sokoto goats using chloramphenicol 25 mg kg-1. Following the drug administration intravenously and intramuscularly samples of plasma were obtained in the goats at various time intervals. Measurable blood levels of the drug were obtained in goats for 6 h after intravenous injection and for 9 h after intramuscular administration. A mean plasma concentration of chloramphenicol (25.63 2.01 ¦Ìg mL-1) was obtained at 0.08 h (5 min) after the intravenous administration of the drug while the peak plasma concentration of the drug following intramuscular treatment was 9.64 0.74  g mL-1 after 0.25 h (30 min). The apparent volume of distribution and the total body clearance of chloramphenicol from the Sokoto red goats  were  higher after intramuscular than intravenous administration. About 80% of the drug administered intramuscularly reached the plasma. This result has yielded baseline data for further investigation(s) of the drug.
%U http://docsdrive.com/pdfs/ansinet/ijp/2005/239-243.pdf