%0 Journal Article
%T HYPOGLYCEMIC EFFECT OF 2-HYDROXYCHALCONE ON HIGH FRUCTOSE FED DIABETIC RAT
%A K. Jegatheesan et al.
%J International Journal of Pharmaceutical Sciences and Research
%D 2012
%I Society of Pharmaceutical Sciences and Research
%X The objective of the project work was to study the effect of Hypoglycemic and Hypolipidemic activity of 2- hydroxychalcone on high fructose diet induced insulin resistance in male Wister Albino rats. Rats were rendered insulin resistant by feeding 66% (w/w) fructose and 1.1% (v/w) coconut oil mixed with normal pellet diet (NPD) for 3 weeks. Insulin resistance high fructose diabetic rats receiving hydroxychalcone intraperitoneally (i.p.) at the dose of 25mg/kg body weight daily for 7 consecutive days. At the end of the study blood glucose, serum insulin, glycosylated haemoglobin was estimated. The tissue was used for the assay of enzyme activity of Hexokinase, Glycogen, Glu-6-phosphatase and fru-1, 6 bis phosphatase were also estimated. Fructose diet with 2-hydroxychalcone significantly reduced the blood glucose, insulin, glu-6-phosphatase, fru-1, 6 bis phosphatase and significantly increase the hexokinase and glycogen activity. The flavonoid present in the cinnamon 2-hydroxychalcone were found to exhibit a significant Hypoglycemic activity in fructose fed insulin resistant rats.
%K Hydroxychalcone
%K HFD
%K Insulin
%K Pioglitazone
%K DMSO
%U http://ijpsr.com/V3I2/46%20Vol.%203,%20Issue%202,%20Feb.%202012,%20IJPSR-1059,%20Paper%2046.pdf