%0 Journal Article
%T ANTIDIABETIC POTENTIAL OF BERBERIS ARISTATA BARK IN ALLOXAN INDUCED DIABETIC RATS
%A Arshad Ahmad*
%A A. Pandurangan
%A Sameksha Koul and B.M Sharma
%J International Journal of Pharmaceutical Sciences and Research
%D 2012
%I Society of Pharmaceutical Sciences and Research
%X The present study was designed to investigate the antidiabetic potential of different extracts of Berberis aristata bark, in alloxan induced diabetic male wister albino rats (150-250g), Diabetes was confirmed after 5 days of single intraperitoneally injection of alloxan (140 mg/kg of body wt.) in 12 hours previously fasted rats. Petroleum ether extract of Berberis aristata (PEBA) (100 & 400 mg/kg, body wt.) & Ethanolic extract of Berberis aristata (EEBA) (100 & 400 mg/kg, body wt.) and the standard drug glibenclamide (10 mg/kg, body wt.) were given orally in 0.5% Tween 80 after 5 days of alloxan treatment daily for 20 days, except the normal and diabetic control group (n=6). Blood was collected from the retro orbital sinus of the rats for glucose, total cholesterol and triglyceride level determination on 1st, 5th, 10th and 20th days. PEBA (100 & 400 mg/kg, body wt.) showed significant reduction in blood glucose level (266.3 ¡À 0.9700 to 118.1 ¡À 0.9375mg/dl & 271.3 ¡À 0.6983 to 111.6 ¡À 0.8072 mg/dl, respectively), total cholesterol (92.40¡À0.7711mg/dl & 88.95¡À0.8144mg/dl, respectively) and triglycerides (78.58¡À0.9250mg/dl & 69.30¡À0.8963mg/dl, respectively) and EEBA (100 & 400 mg/kg, body wt.) showed significant reduction in blood glucose level (264 ¡À 0.7881 to 115.8 ¡À 0.8931 mg/dl & 278.9 ¡À 0.6906 to 101.80 ¡À 0.7490 mg/dl, respectively), total cholesterol (87.80¡À0.4683 mg/dl and 83.55¡À0.7680 mg/dl, respectively) and triglycerides (74.47¡À0.5748 mg/dl & 67.52¡À0.6833 mg/dl, respectively) that comparable to glibenclamide showed significant reduction in blood glucose level (251.8¡À0.6009 to 99.17¡À0.5283 mg/dl), total cholesterol (82.66¡À0.5845 mg/dl) and triglycerides (62.07¡À0.5175 mg/dl). It is concluded that PEBA & EEBA (400 mg/kg) possess better antidiabetic potential in alloxan induced diabetic rats.
%K Berberis aristata
%K Alloxan
%K Glibenclamide
%K Diabetes
%U http://www.ijpsr.com/V3I11/55%20Vol.%203,%20Issue%2011,%20Nov.%202012,%20IJPSR,%20RA%201847,%20Paper%2055.pdf