%0 Journal Article
%T Theoretical Study of the Schiff B ase Formation B etween Para - Substituted Aromatic Amines and Thiophene - 2 - C arbaldehyde
%A Musa E. Mohamed
%A Christina Y. Ishak
%A Hajir I.Wahbi
%J International Journal of Pharmaceutical and Phytopharmacological Research
%D 2013
%I International Journal of Pharmaceutical and Phytopharmacological Research
%X Theoretical study based on the Restricted Hartree-Fock calculations (RHF/3-21G) of the formation of Schiff base of para-methoxyaniline, para-methylaniline and anline with thiophene-2-carbaldehyde was conducted. The reaction mechanism wasfound to involve two steps, namely: (1) formation of a carbinolamine and (2) dehydration of the carbinolamine to give the finalschiff base, through six-membered ring transition states. The carbinolamine is intermediate and dehydration is rate determiningstep of the reaction. The formation of Schiff base between the para-substituented aniline and thiopheneadehyde requires thecontribution of one auxiliary water molecule as a true reactive in order to facilitate proton transfer, and allows the nucleophilicattack of the incoming amine to carbonyl group. The para-methoxy substituent has less energy barrier than the other twosubstituents, according to more electron withdrawing effect.
%K Schiff base
%K Six - membered ring transition state
%K Restricted Hartree - Fock
%K T hiophene - 2 - carbaldehyde .
%U http://www.eijppr.com/nov-dec2012/7.pdf