%0 Journal Article %T GnRH agonist versus GnRH antagonist in assisted reproduction cycles: oocyte morphology %A Ana Marcia M Cota %A Joao Batista A Oliveira %A Claudia G Petersen %A Ana L Mauri %A Fabiana C Massaro %A Liliane FI Silva %A Andreia Nicoletti %A Mario Cavagna %A Ricardo RL Baruffi %A Jos¨¦ G Franco %J Reproductive Biology and Endocrinology %D 2012 %I BioMed Central %R 10.1186/1477-7827-10-33 %X A total of 64 patients in the first intracytoplasmic sperm injection (ICSI) cycle were prospectively randomized to receive treatment with either a GnRH agonist with a long-term protocol (n: 32) or a GnRH antagonist with a multi-dose protocol (n: 32). Before being subjected to ICSI, the oocytes at metaphase II from both groups were morphologically analyzed under an inverted light microscope at 400x magnification. The oocytes were classified as follows: normal or with cytoplasmic dysmorphism, extracytoplasmic dysmorphism, or both. The number of dysmorphic oocytes per total number of oocytes was analyzed.Out of a total of 681 oocytes, 189 (27.8£¿%) were morphologically normal, 220 (32.3£¿%) showed cytoplasmic dysmorphism, 124 (18.2%) showed extracytoplasmic alterations, and 148 (21.7%) exhibited both types of dysmorphism. No significant difference in oocyte dysmorphism was observed between the agonist- and antagonist-treated groups (P£¿£¿£¿0.05). Analysis for each dysmorphism revealed that the most common conditions were alterations in polar body shape (31.3%) and the presence of diffuse cytoplasmic granulations (22.8%), refractile bodies (18.5%) and central cytoplasmic granulations (13.6%). There was no significant difference among individual oocyte dysmorphisms in the agonist- and antagonist-treated groups (P£¿£¿£¿0.05).Our randomized data indicate that in terms of the quality of oocyte morphology, there is no difference between the antagonist multi-dose protocol and the long-term agonist protocol. If a GnRH analogue used for pituitary suppression in IVF cycles influences the prevalence of oocyte dysmorphisms, there does not appear to be a difference between the use of an agonist as opposed to an antagonist. %K Oocyte morphology %K in vitro fertilization %K Gonadotropin-releasing hormone analogues %K Assisted reproduction technique %U http://www.rbej.com/content/10/1/33/abstract