%0 Journal Article
%T Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome
%A Nana Liu
%A Yanmin Ma
%A Shuyu Wang
%A Xiaowei Zhang
%A Qiufang Zhang
%A Xue Zhang
%A Li Fu
%A Jie Qiao
%J Reproductive Biology and Endocrinology
%D 2012
%I BioMed Central
%R 10.1186/1477-7827-10-36
%X 315 PCOS women and 212 controls were screened for the gene variants of LH G1052A and LHR rs61996318 polymorphisms by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).PCOS patients had significantly more A allele frequency of LH G1052A mutations than controls (p=0.001). Within PCOS group, carriers of LH 1052A allele had lower LH (p=0.05) and higher fasting glucose levels (p=0.04). No subjects were identified with LHR rs61996318 polymorphisms. A new LHR single nucleotide polymorphism (SNP) was found without clear association with PCOS.Results suggested LH G1052A mutation might influence PCOS susceptibility and phenotypes.
%K Luteinizing hormone
%K Luteinizing hormone receptor
%K Polycystic ovary syndrome
%K Gene polymorphism
%U http://www.rbej.com/content/10/1/36/abstract