%0 Journal Article
%T The influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin¡¯s lymphoma in Ukrainian patients
%A Kriachok I. A.
%A Khranovska N. M.
%A Svergun N. M.
%A Filonenko K. S.
%J Biopolymers and Cell
%D 2012
%I Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine
%X The aim of this research was to study the influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin¡¯s lymphoma in Ukrainian patients. Methods. The polymorphic variants of GSTP1 gene were analyzed using Allelic Discrimination Real-Time PCR. Results. The GSTP1 polymorphism is not directly involved in the development of Hodgkin¡¯s lymphoma and chemotherapy-related toxicity, but homozygous wild genotype of this gene is associated with a worse clinical response to the therapy and a higher risk of relapse. Conclusions. The investigation of GSTP1 polymorphism is very promising, since it might provide a possible application of this genetic marker as an independent prognostic factor of Hodgkin¡¯s lymphoma.
%K Hodgkin¡¯s lymphoma
%K polymorphism
%K GSTP1 gene
%U http://www.biopolymers.org.ua/archive/2012/01/09.pdf