%0 Journal Article %T The peculiarities of gene expression of medullary breast carcinoma tumor-associated antigensin different types of breast tumors %A Shyian M. A. %A Kostianets O. I. %A Tsuvariev O. Yu. %A Stolyaruk A. V. %J Biopolymers and Cell %D 2012 %I Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine %X Aim. To investigate gene expression profile of human medullary breast carcinoma¡¯s tumor-associated antigens in different histological types of breast tumors. To analyze §Ñ correlation between alterations in gene expression level and induction of immune response against the corresponding antigens. Methods. Real-time polymerase chain reaction. Results. Differential gene expression profile of 6 (RAD50, HMGN2, RBPJ, PABPC4, BRAP, DEK) medullary breast carcinoma tumor-associated antigens have been revealed in breast tumors of different histological types. Correlation between changes in tumor-associated antigens gene expression level and induction of immune response has not been found. Conclusions. The genes of human medullary breast carcinoma tumor-associated antigens with differential expression profile in different histological types of breast tumors are potential diagnostic markers of breast cancer. Alteration of tumor-associated antigens gene expression level is not a prelude to an immune response against their corresponding protein products. %K medullary breast carcinoma %K tumor-associated antigens %K immunoreactivity %U http://www.biopolymers.org.ua/pdf/uk/28/5/381/