%0 Journal Article
%T Distinct degree of radiculopathy at different levels of peripheral nerve injury
%A Noboru Takiguchi
%A Munehito Yoshida
%A Wataru Taniguchi
%A Hiroshi Hashizume
%A Hiroshi Yamada
%A Nobuyuki Miyazaki
%A Naoko Nishio
%A Terumasa Nakatsuka
%J Molecular Pain
%D 2012
%I BioMed Central
%R 10.1186/1744-8069-8-31
%X The lumbar radiculopathy rat model was created by ligating the L5 nerve root 2£¿mm proximal to the DRG or 2£¿mm distal to the DRG with 6.0 silk. We examined the degree of the radiculopathy using different points of mechanical sensitivity, immunohistochemistry and in vivo patch-clamp recordings, 7£¿days after surgery. The rats injured distal to the DRG were more sensitive than those rats injured proximal to the DRG in the behavioral study. The number of activated microglia in laminas I¨CII of the L5 segmental level was significantly increased in rats injured distal to the DRG when compared with rats injured proximal to the DRG. The amplitudes and frequencies of EPSC in the rats injured distal to the DRG were higher than those injured proximal to the DRG. The results indicated that there is a different degree of radiculopathy at the distal level of nerve injury.Our study examined the degree of radiculopathy at different levels of nerve injury. Severe radiculopathy occurred in rats injured distal to the DRG when compared with rats injured proximal to the DRG. This finding helps to correctly diagnose a radiculopathy.
%K Radiculopathy
%K Microglia
%K Patch-clamp
%U http://www.molecularpain.com/content/8/1/31/abstract