%0 Journal Article
%T Engineered cellular carrier nanoerythrosomes as potential targeting vectors for anti-malarial drug
%A Agnihotri Jaya
%A Gajbhiye Virendra
%A Jain Narendra
%J Asian Journal of Pharmaceutics
%D 2010
%I Medknow Publications
%X The present investigation was aimed at developing and exploring the use of nanoerythrosomes (nEs) for targeted delivery of anti-malarial drug, pyrimethamine (PMA). The formulation was prepared by the extrusion method and drug was conjugated to nEs with the help of gluteraldehyde used as a cross-linking agent. The nEs formulation was optimized for drug concentration, surface morphology, viscosity, and sedimentation volume. The drug-loaded nEs showed delayed in vitro release, good stability at 4¡À1¡ãC, and controlled in vivo release. Tissue distribution studies showed higher accumulation of drug in liver (17.34¡À1.3 ¦Ìg/ml) at 3 h in the case of nEs as compared to free drug (12.82¡À0.7 ¦Ìg/ml). A higher amount of drug i.e. 13.14¡À0.9 ¦Ìg/ml was found after 24 h in liver in the case of nEs as compared to free drug concentration of 9.72¡À0.5 ¦Ìg/ml. Data showed that developed PMA-loaded nEs hold promise for targeting and controlling the release of drug and improve treatment of malaria.
%K Anti-malarial
%K cellular carrier
%K nanoerythrosomes
%K pyrimethamine
%K targeting
%U http://www.asiapharmaceutics.info/article.asp?issn=0973-8398;year=2010;volume=4;issue=2;spage=116;epage=120;aulast=Agnihotri