%0 Journal Article
%T Effect of method of preparation on pioglitazone HCl-¦Â-cyclodextrin inclusion complexes
%A Beloshe Shrikant
%A Chougule Dhanyakumar
%A Shah Rohit
%A Ghodke Dhananjay
%J Asian Journal of Pharmaceutics
%D 2010
%I Medknow Publications
%X Pioglitazone HCl is an antidiabetic agent with poor aqueous solubility. Inclusion complexes of pioglitazone HCl were prepared with ¦Â-cyclodextrin using various methods (physical mixing, kneading method, co-precipitation). The main aim of the present invention is to study the effect of the method of preparation on the dissolution profiles of pioglitazone HCl-¦Â-Cyclodextrin inclusion complexes . The phase solubility profile of pioglitazone HCl with ¦Â-cyclodextrin was classified as AL-type and stability constant with 1:1 molar ratio was 115.45, calculated from the phase solubility diagram. Formation of the inclusion complex between pioglitazone HCl and ¦Â-cyclodextrin was confirmed by the Fourier Transform Infrared (FT-IR) spectroscopy. The dissolution profile of inclusion complexes were determined and compared with those of pioglitazone HCl alone and its physical mixtures. The dissolution rate of the pioglitazone HCl-¦Â-cyclodextrin inclusion complex prepared by the co-precipitation method was six times higher when compared with the pure drug. The method of complexation of pioglitazone HCl in ¦Â-CD increased the dissolution rate of the drug in the following order: Coppt > KM > PM >Drug.
%K Inclusion complex
%K pioglitazone HCl
%K ¦Â-cyclodextrin
%U http://www.asiapharmaceutics.info/article.asp?issn=0973-8398;year=2010;volume=4;issue=2;spage=168;epage=172;aulast=Beloshe