%0 Journal Article
%T Preparation, physicochemical characterization, dissolution and formulation studies of telmisartan cyclodextrin inclusion complexes
%A Kane Rajesh
%A Kuchekar Bhanudas
%J Asian Journal of Pharmaceutics
%D 2010
%I Medknow Publications
%X The objective of this research was to prepare, characterize, and to study dissolution properties of inclusion complexes of telmisartan (TLM), with ¦Â-cyclodextrin and hydroxypropyl-¦Â-cyclodextrin and to study effect of complexation on aqueous solubility and rate of dissolution in dissolution media. The phase solubility curve was classified as an A P type for both the CDs, which indicated formation of the inclusion complex of TLM in 1:2 stoichiometries with ¦Â-CD and HP-¦Â-CD. The inclusion complexes in molar ratio of 1:2 were prepared by various methods. The molecular behavior of TLM in all samples were characterized by Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and powder X-ray diffraction studies. The result of studies showed inclusion of TLM molecule into cyclodextrin cavities. The highest improvement in in-vitro dissolution of TLM was observed in a complex prepared with HP¦Â-CD using the kneading method. Mean dissolution time (MDT) and similarity factor (f2) indicated a significant difference between the release profile of TLM from complexes, physical mixture, and pure TLM. The highest improvement in solubility and in-vitro drug release were observed in inclusion complex prepared with HP-¦Â-CD by kneading method. Improvement in solubility and in-vitro drug release of telmisartan was more with HP-¦Â-CD as compared to ¦Â-CD
%K ¦Â-cyclodextrin
%K dissolution studies
%K hydroxypropyl-¦Â-cyclodextrin
%K inclusion complexes
%K telmisartan
%U http://www.asiapharmaceutics.info/article.asp?issn=0973-8398;year=2010;volume=4;issue=1;spage=52;epage=59;aulast=Kane