%0 Journal Article
%T HLA-A24: factor de riesgo en retinopat¨ªa diab¨¦tica proliferante HLA-A24: risk factor in proliferante diabetic retinopathy
%A V.M. Asensio-S¨¢nchez
%A B. Rodr¨ªguez-Delgado
%A E. Garc¨ªa-Herrero
%A V. Cabo-Vaquera
%J Archivos de la Sociedad Espa£¿ola de Oftalmolog¨ªa
%D 2007
%I Scientific Electronic Library Online
%X Objetivo: La retinopat¨ªa diab¨¦tica proliferante (RDP) se caracteriza por p¨¦rdida de la visi¨®n en la poblaci¨®n joven. Est¨¢ bien establecido que el ant¨ªgeno leucocitario humano (HLA)-A24 es un factor de riesgo para la p¨¦rdida total de las c¨¦lulas  del p¨¢ncreas. Nuestro objetivo es estudiar la asociaci¨®n del HLA-A24 con la RDP. Material y m¨¦todo: Se estudi¨® un grupo de pacientes con RDP (n= 95) y un grupo control (n= 60). A todos se les determin¨® el HLA-A24 mediante t¨¦cnicas hibridaci¨®n molecular. Resultados: El grupo control mostr¨® menos frecuencia de HLA-A24 que el grupo con RDP (p= 0,043). El HLA-A24 se asoci¨® a retinopat¨ªa diab¨¦tica proliferante (OR = 5,4; 95% CI= 3,2-7,6; p< 0,001). Conclusiones: El HLA-A24 no es un factor de protecci¨®n para la retinopat¨ªa diab¨¦tica proliferante, es un factor de riesgo para desarrollarla. Objective: Proliferative diabetic retinopathy (PDR) is characterized by a progressive visual impairment in young people. Human leucocyte antigen (HLA)-A24 is a well-established factor associated with the pancreatic islets of Langerhans lost in this process. Our aim was to study further the relationship of the HLA-A24 associated with PDR. Materials and methods: We evaluated a group of patients with PDR (n=95) and a healthy control group (n= 60). HLA-A24 for each participant in the study was determined by molecular hybridization techniques. Results: The control group showed a lower frequency of HLA-A24 compared with the PDR group (p = 0.043). HLA-A24 was associated with PDR (OR = 5.4; 95% CI= 3.2-7.6; p< 0.001). Conclusions: HLA-A24 is not a protective factor for PDR, but is a risk factor of its development.
%K Diabetes insulindependiente
%K retinopat¨ªa diab¨¦tica proliferante
%K HLA
%K HLA-A24
%K factor de riesgo
%K Insulin-dependent diabetes
%K proliferative diabetic retinopathy
%K HLA
%K HLA-A24
%K risk factor
%U http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0365-66912007001200007