%0 Journal Article
%T Expression of p53, Ki-67 and c-erb B2 in growth hormone-and/or prolactin-secreting pituitary adenomas
%A Botelho Carlos Henrique A.
%A Magalh£żes Albino Ver£żosa de
%A Mello Paulo Andrade de
%A Schmitt Fernando C.
%J Arquivos de Neuro-Psiquiatria
%D 2006
%I Academia Brasileira de Neurologia - ABNEURO
%X The subcellular events implicated on the formation and behavior of pituitary adenomas are not fully understood. In this study we investigated the presence of p53, Ki-67 and c-erb B2 in 38 pituitary adenomas with immunohistochemical positivity for GH and prolactin (n=26; 68.4%), for prolactin (n=9; 23.7%) and for GH (n=3. 7.8%). The analyses revealed the following results: 24 (63.2%) tumors expressed variable positivity for c-erb B2, 11 (28.9%) expressed p53 positivity and 11 (28.9%) tumors were variably positive for Ki-67. Our results demonstrated a high percentage of GH/prolactin-, prolactin- and GH-secreting tumors with immunohistochemical positivity for c-erb B2. Once this membrane receptor is related to growth factors EGF and TGFalpha and both have a definite effect on tumor growth, our data suggest a possible role for c-erb B2 on the evolution of these tumors.
%K pituitary adenomas
%K growth hormone
%K prolactin
%K p53
%K Ki-67
%K c-erb B2
%K immunohistochemistry
%U http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000100013