%0 Journal Article
%T Does bicarbonated mineral water rich in sodium change insulin sensitivity of postmenopausal women?  Modifica el agua mineral bicarbonatada rica en sodio la sensibilidad a la insulina de las mujeres postmenop¨¢usicas?
%A S. Schoppen
%A F. J. S¨¢nchez-Muniz
%A A. M.a P¨¦rez-Granados
%A J. A. G¨®mez-Gerique
%J Nutrici¨®n Hospitalaria
%D 2007
%I Sociedad Espa?ola de Nutrici¨®n Parenteral y Enteral
%X Aim: To study the effects of drinking 0.5 L of two sodium-rich bicarbonated mineral waters (BMW-1 and 2), with a standard meal, on postprandial insulin and glucose changes. And to determine, if the effects vary depending on insulin resistance, measured by homeostasis model assessment (HOMA). Methods: In a 3-way randomized crossover study, 18 healthy postmenopausal women consumed two sodiumrich BMWs and a low-mineral water (LMW) with a standard fat-rich meal. Fasting and postprandial blood samples were taken at 30, 60 and 120 min. Serum glucose, insulin, cholesterol and triacylglycerols were determined. Insulin resistance was estimated by HOMA and insulin sensitivity was calculated by quantitative insulin sensitivity check index (QUICKY). Results: Glucose levels did not change. HOMA and QUICKY values were highly inversely correlated (r = -1,000; p < 0.0001). Insulin concentrations showed a significant time effect (p < 0.0001) and a significant water x time interaction (p < 0.021). At 120 min insulin levels with BMW-1 were significantly lower than with LMW (p = 0.022). Postprandial insulin concentrations showed significantly different patterns of mineral water intake depending on HOMA n-tiles (p = 0.016). Conclusion: Results suggests an increase in insulin sensitivity after BMWs consumption. This effect is more marked in the women, who have higher HOMA values. These waters should be considered part of a healthy diet in order to prevent insulin resistance and cardiovascular disease. Objetivo: Estudiar los efectos de la ingesta de 0.5L de dos aguas minerales bicarbonatadas ricas en sodio (BMW-1 y 2), junto con una comida est¨¢ndar, sobre los cambios en la insulina y la glucosa postprandial; y determinar si los posibles efectos var¨ªan en funci¨®n de la resistencia a la insulina evaluada a trav¨¦s del modelo homeost¨¢tico (HOMA). M¨¦todos: 18 mujeres postmenop¨¢usicas sanas participaron en un estudio triple cruzado aleatorizado, en el que bebieron 2 aguas minerales bicarbonatadas ricas en sodio (BMW-1 y 2) y un agua mineral d¨¦bil (LMW) junto con una comida est¨¢ndar rica en grasa. Se tomaron muestras de sangre en ayunas y postprandiales a los 30, 60 y 120 min. Se determin¨® glucosa, insulina, colesterol y triglic¨¦ridos en suero. La resistencia a la insulina fue estimada a trav¨¦s del HOMA y la sensibilidad a la insulina se calcul¨® mediante el ¨ªndice de sensibilidad cuantitativa a la insulina (QUICKY). Resultados: Los niveles de glucosa no presentaron cambios. Los valores de HOMA y QUICKY presentaron una fuerte correlaci¨®n inversa (r = -1,000; p < 0,0001). Las concentr
%K Agua mineral bicarbonatada
%K Insulina
%K Glucosa
%K Sodio
%K Fl¨²or
%K Bicarbonated mineral water
%K Insulin
%K Glucose
%K Sodium
%K Fluoride
%U http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112007000700003