%0 Journal Article
%T Elevated serum levels of interleukin-17A in children with autism
%A Laila Yousef AL-Ayadhi
%A Gehan Ahmed Mostafa
%J Journal of Neuroinflammation
%D 2012
%I BioMed Central
%R 10.1186/1742-2094-9-158
%X Serum IL-17A levels were measured by ELISA in 45 children with autism and 40 matched healthy controls.Children with autism had significantly higher serum IL-17A levels than healthy controls (P <0.001), with increased serum levels of IL-17A found in 48.9% of the autism group. Patients with severe autism had significantly higher serum IL-17A levels than those with mild to moderate autism (P£¿=£¿0.01), and raised serum IL-17A levels were significantly more common in children with severe autism (67.9%) than in those with mild to moderate autism (17.6%), P£¿=£¿0.001.Serum IL-17A levels were raised in the group with autism, and the levels correlated significantly with the severity of autism. This is the first study to measure levels of IL-17A in relation to the severity of autism, to our knowledge. Further research, with a larger subject population, is warranted to determine whether the increase of serum IL-17A levels plasma has a pathogenic role in autism, and whether anti- IL-17A therapy could be useful
%K Autism
%K Autoimmunity
%K Childhood autism rating scale
%K IL-17A
%K T-helper 17
%U http://www.jneuroinflammation.com/content/9/1/158/abstract