%0 Journal Article
%T ANTITUMOR ACTIVITY OF CAPPARIS SEPIARIA ON EHRLICH ASCITES CARCINOMA IN MICE
%A Y VenuGopal
%A Ravindranath A
%A Kalpana G
%A Prabhaker Reddy.V
%J International Journal of Biomedical Research
%D 2013
%I 
%R 10.7439/ijbr.v2i4.103
%X The methanol extract of Capparis Sepiaria (Capparaceae) bark (MECS) were evaluated for antitumor activity against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. The extract was administered at the doses of 200, and 400 mg/kg body weight per day for 14 days after 24 h of tumor inoculation. After the last dose and 18 h fasting, the mice were sacrificed. The present study deals with the effect of MECS on the growth of transplantable murine tumor, life span of EAC-bearing hosts and hematological profile   MECS caused significant (P < 0.01) decrease in tumor volume, packed cell volume, and viable cell count; and it prolonged the life span of EAC-tumor bearing mice. Hematological profile converted to more or less normal levels in extract-treated mice. The results indicate that MECS exhibited significant antitumor     activity in EAC-bearing mice.
%K Capparis sepiaria
%K Ehrlich ascites carcinoma
%K Antitumor
%U http://ijbr.ssjournals.com/index.php/journal/article/view/32