%0 Journal Article
%T Impact of orocecal transit time on patient's perception of lactose intolerance Influencia del tiempo de tr¨¢nsito orocecal en la percepci¨®n de los s¨ªntomas de intolerancia a la lactosa
%A Francesc Casellas
%A Anna Aparici
%A Maite Casaus
%A Purificaci¨®n Rodr¨ªguez
%J Revista Espa£¿ola de Enfermedades Digestivas
%D 2013
%I The Spanish Society of Digestive Pathology
%X Background: symptoms attributed to the lactose intolerance are an important public health issue because of their prevalence and social relevance. Also because they may cause undue rejection of dairy products consume with potential health consequences. Transit time is a putative factor implied in the severity of symptoms associated with lactose. Objectives: to elucidate the relation between orocecal transit time (OCTT) and lactose intolerance symptoms. Methods: observational study in patients referred to a lactose hydrogen breath test who showed an increase in breath H2 excretion higher than 25 ppm. OCTT was measured with the breath test and symptoms of lactose tolerance with a validated scale. Symptoms were measured twice: before receiving the lactose, inquiring about self perceived symptoms when patients consumed dairy products at home ("home symptoms"), and again after completing the lactose breath test ("test symptoms"). Results: 161 patients were included. There was no correlation between OCTT and home symptoms (r = -0.1). When OCTT was faster than 60 minutes, intensity of "test symptoms" was similar to "home symptoms". However, in patients with normal or slow OCTT, the "home symptoms" were more intense than the "test symptoms" (p < 0.05). At home, symptoms were independent of OCTT but with the lactose test load the symptoms were proportionately more intense with faster OCTT. Conclusions: in lactose maldigesters, selfreported symptoms of lactose intolerance are more pronounced at home than after a high lactose challenge. Intolerance symptoms that patients attributed to lactose consume at home are due to factors other than fast OCTT. Antecedentes: los s¨ªntomas atribuidos a la intolerancia a la lactosa son un importante problema de salud p¨²blica. El tiempo de tr¨¢nsito es un factor implicado en la severidad de los s¨ªntomas asociados al consumo de lactosa. Objetivos: elucidar la relaci¨®n entre el tiempo de tr¨¢nsito orocecal (TTOC) y los s¨ªntomas de intolerancia a la lactosa. M¨¦todos: estudio observacional en pacientes con un test del aliento de hidr¨®geno con lactosa patol¨®gico (excreci¨®n de hidr¨®geno superior a 25 ppm). El TTOC se midi¨® mediante el test del aliento y los s¨ªntomas mediante una escala previamente validada. Los s¨ªntomas se determinaron dos veces: antes de recibir la lactosa, preguntando acerca de los s¨ªntomas en casa cuando se consumen l¨¢cteos ("s¨ªntomas en casa"), y de nuevo despu¨¦s de completar el test del aliento con lactosa ("s¨ªntomas test"). Resultados: se han incluido 161 pacientes. No se observa correlaci¨®n entre el TTOC y los s¨ªnto
%K Intolerancia a la lactosa
%K Malabsorci¨®n de lactosa
%K Test del aliento de hidr¨®geno
%K Actividad lact¨¢sica
%K Tiempo de tr¨¢nsito orocecal
%K Lactose intolerance
%K Lactose malabsorption
%K Hydrogen breath test
%K Lactase activity
%K Transit time
%K Orocecal transit time
%U http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082013000100004