%0 Journal Article
%T Thrombolytic therapy in patients with acute myocardial infarction
%A E.V. Konstantinova
%A A.V. Magnitskyi
%A N.A. Schostak
%J Rational Pharmacotherapy in Cardiology
%D 2006
%I Rational Pharmacotherapy in Cardiology
%X It is reported that the implementation in clinical practice thrombolytic (fibrinolytic) therapy resulted in mortality reduction during first month after myocardial infarction from 17-18% to 5-8%. Different details of this therapy are considered: terms of thrombolysis since the beginning of myocardial infarction, alternative methods of coronary blood flow recovery, indications and contraindications, complications and side effects, estimation of thrombolysis efficacy. Fibrin-selective and fibrin-non-selective drugs are presented. Different fibrinolytics are described: streptokinase, anistreplase, alteplase, reteplase, tenekteplase. The results of large randomized clinical trials devoted to fibrinolytic therapy of myocardial infarction are analyzed: GISSI, ISSIS, TIMI, GUSTO, INJECT, ASSENT. The possibility to increase in efficacy and safety of fibrinolytics by their combination with acetylsalicylic acid, IIb/IIIa receptor inhibitors and heparins are discussed.
%K myocardial infarction
%K thrombolysis
%K fibrinolytics
%K streptokinase
%K anistreplase
%K alteplase
%K reteplase
%K tenekteplase.
%U http://www.rpcardio.com/archive/article.php?ID=2992