%0 Journal Article
%T Possible predictors of atrial fibrillation recurrence in long-term prophylactic propafenone therapy
%A R.D. Kurbanov
%A N.U. Zakirov
%A Sh.K. Azizov
%A Kh.M. Raubzhanov
%J Rational Pharmacotherapy in Cardiology
%D 2012
%I Rational Pharmacotherapy in Cardiology
%X Aim. To identify possible predictors of atrial fibrillation (AF) recurrence in 6-month prophylactic propafenone therapy.Material and methods. Patients (n=63; aged 52.2¡À12.6 years; 25.4% women) with frequent AF recurrences who restored sinus rhythm with propafenone, were included into the study. Paroxysmal AF was observed in 84.1% of patients, and persistent AF ¡ª in 15.9% of patients. ECG, transthoracic echocardiography, chest radiography with the calculation of cardio-thoracic index (CTI) was performed at baseline. All patients received rpropafenone therapy (450¨C600 mg/day) during 6 months after sinus rhythm conversion. ECG and 24-hours ECG monitoring were performed in 1, 3 and 6 months of the therapy. Patients with 70¨C100% reduction in AF recurrence rate were included into the 1-st group, and patients with <70% reduction ¨C into the 2-nd group.Results. 92%, 88.5% and 78% of patients were included into the group 1 after 1, 3 and 6 months of follow up, respectively. AF recurrences were observed 4.5, 3.8, and 1.7 times more often in women than these in men after 1, 3 and 6 months, respectively, (p>0.05). Mean age of patients in the group 2 was significantly older than this in patients of the group 1 (p<0.05). CTI, left atrium size and volume, interventricular septum thickness (IVST) were significantly larger in group 2. Myocardium mass of the left ventricle (MMLV) after 6 months of therapy was larger by 13.9% in patients of the group 2 vs this in patients of the group 1 (p<0.05).Conclusion. Insufficient preventive effect of propafenone was observed in 8%, 11.5% and 22% of patients in 1, 3 and 6 months of the follow-up, respectively. Propafenone prophylactic efficacy was slightly higher in men and younger patients. Patients with poor preventive effect of propafenone had a significantly larger baseline CTI, size and volume of the left atrium, IVST, and MMLV.
%K recurrent atrial fibrillation
%K propafenone
%K predictors
%U http://www.rpcardio.com/archive/article.php?ID=3693