%0 Journal Article
%T Fanconi anemia and vaginal squamous cell carcinoma
%A Altamiro Ribeiro Dias Jr.
%A Marcela Cavalcante de Andrade Silva
%A Filomena Marino de Carvalho
%A Heloisa de Andrade Carvalho
%J Rare Tumors
%D 2012
%I PAGEPress Publications
%R 10.4081/rt.2012.e4
%X Fanconi Anemia (FA) is an autosomal recessive disease characterized by chromosome instability, cellular hypersensitivity to DNA cross-linking agents, and increased predisposition to malignancies. We describe here a 28 year-old female with FA and vaginal squamous cell carcinoma treated by radiation therapy alone. The patient developed arm phlebitis, pulmonary fungal infection, and severe rectal bleeding, followed by hypocalcaemia, hypokalemia, vaginal bacterial and fungal infection, with subsequent leg and arm phlebitis, perineal abscess, and sepsis. The patient died 12 weeks later.
%K Fanconi anemia
%K squamous cell carcinoma
%K radiation therapy
%K proctitis
%K hemorrhage
%U http://www.pagepress.org/journals/index.php/rt/article/view/2960