%0 Journal Article
%T Risk factors for adverse outcome in low rectal cancer
%A Zhi-Hui Chen
%A Xin-Ming Song
%A Shi-Cai Chen
%A Ming-Zhe Li
%J World Journal of Gastroenterology
%D 2012
%I Baishideng Publishing Group Co. Limited
%R 10.3748/wjg.v18.i1.64
%X AIM: To demonstrate the oncologic outcomes of low rectal cancer and to clarify the risk factors for survival, focusing particularly on the type of surgery performed. METHODS: Data from patients with low rectal carcinomas who underwent surgery, either sphincter-preserving surgery (SPS) or abdominoperineal resection (APR), at The First Affiliated Hospital of Sun Yat-sen University in China from August 1994 to December 2005 were retrospectively analyzed. RESULTS: Of 331 patients with low rectal cancer, 159 (48.0%) were treated with SPS. A higher incidence of positive resection margins and a higher 5-year cumulative local recurrence rate (14.7% vs 6.8%, P = 0.041) were observed in patients after APR compared to SPS. The five-year overall survival (OS) was 54.6% after APR and 66.8% after SPS (P = 0.018), and the 5-year disease-free survival (DFS) was 52.9% after APR and 65.5% after SPS (P = 0.013). In multivariate analysis, poor OS and DFS were significantly related to positive resection margins, pT3-4, and pTNM III-IV but not to the type of surgery. CONCLUSION: Despite a higher rate of positive resection margins after APR, the type of surgery was not identified as an independent risk factor for survival.
%K Abdominoperineal resection
%K Prognosis
%K Rectal neoplasms
%K Sphincter-preserving surgery
%K Surgery
%U http://www.wjgnet.com/1007-9327/full/v18/i1/64.htm