%0 Journal Article
%T Kinetics of HIV-1 in cerebrospinal fluid and plasma in cryptococcal meningitis
%A Diego M. Cecchini
%A Ana M. Ca£żizal
%A Haroldo Rojas
%A Alicia Arechavala
%J Infectious Disease Reports
%D 2012
%I PAGEPress Publications
%R 10.4081/idr.2012.e30
%X In order to determine HIV-1 kinetics in cerebrospinal fluid (CSF) and plasma in patients with cryptococcal meningitis (CM), we undertook a prospective collection of paired CSF/plasma samples from antiretroviral therapy- free HIV-infected patients with CM. Samples were obtained at baseline (S1) and at the second (S2) and third (S3) weeks of antifungal therapy. HIV-1 CSF concentrations were significantly lower in both S2 and S3 with respect to S1. Plasma concentrations remained stable. HIV-1 concentrations were higher in plasma than CSF in all cases. Patients who survived the episode of CM (but not those who died) showed a decrease in CSF viral load, what suggests different viral kinetics of HIV-1 in the CSF according to the clinical course of this opportunistic disease.
%K meningitis
%K HIV
%K Cryptococcus neoformans
%K Cerebrospinal fluid
%U http://www.pagepress.org/journals/index.php/idr/article/view/3943