%0 Journal Article
%T The Reaction of Ethyl 2-oxo-2H-chromene-3-carboxylate with Hydrazine Hydrate
%A Hatem A. Abdel-Aziz
%A Tilal Elsaman
%A Mohamed I. Attia
%A Amer M. Alanazi
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18022084
%X Although salicylaldehyde azine ( 3) was reported in 1985 as the single product of the reaction of ethyl 2-oxo-2 H-chromene-3-carboxylate ( 1) with hydrazine hydrate, we identified another main reaction product, besides 3, which was identified as malono-hydrazide ( 4). In the last two decades, however, some articles have claimed that this reaction afforded exclusively hydrazide 2 and they have reported the use of this hydrazide 2 as a precursor in the syntheses of several heterocyclic compounds and hydrazones 6. We reported herein a study of the formation of 2 and a facile route for the synthesis of the target compounds N'-arylidene-2-oxo-2 H-chromene-3-carbohydrazides 6a¨C f.
%K salicylaldehyde azine
%K malonohydrazide
%K coumarins
%K hydrazides/hydrazones
%K ring-opening
%U http://www.mdpi.com/1420-3049/18/2/2084