%0 Journal Article
%T Neuroglobin-overexpression reduces traumatic brain lesion size in mice
%A Song Zhao
%A Zhanyang Yu
%A Gang Zhao
%A Changhong Xing
%A Kazuhide Hayakawa
%A Michael J Whalen
%A Josephine M Lok
%A Eng H Lo
%A Xiaoying Wang
%J BMC Neuroscience
%D 2012
%I BioMed Central
%R 10.1186/1471-2202-13-67
%X Both Ngb over-expression transgenic (Ngb-Tg) and wild-type (WT) control mice were subjected to TBI induced by a controlled cortical impact (CCI) device. TBI significantly increased Ngb expression in the brains of both WT and Ngb-Tg mice, but Ngb-Tg mice had significantly higher Ngb protein levels at the pre-injury baseline and post-TBI. Production of oxidative tissue damage biomarker 3NT in the brain was significantly reduced in Ngb-Tg mice compared to WT controls at 6 hours after TBI. The traumatic brain lesion volume was significantly reduced in Ngb Tg mice compared to WT mice at 3 weeks after TBI; however, there were no significant differences in the recovery of sensorimotor and spatial memory functional deficits between Ngb-Tg and WT control mice for up to 3 weeks after TBI.Ngb over-expression reduced traumatic lesion volume, which might partially be achieved by decreasing oxidative stress.
%K Neuroglobin
%K Neuroprotection
%K Controlled cortical impact
%K Oxidative stress
%K Traumatic brain injury
%U http://www.biomedcentral.com/1471-2202/13/67/abstract