%0 Journal Article
%T Effect of processing variables on dissolution and solubility of piroxicam: Hydroxypropyl-¦Â -cyclodextrin inclusion complexes
%A Doijad R
%A Kanakal M
%A Manvi F
%J Indian Journal of Pharmaceutical Sciences
%D 2007
%I Medknow Publications
%X Influence of processing variables on the solid-state of a model drug, piroxicam in cyclodextrin-based system and its effect on dissolution behavior of the drug was investigated in the present study. Binary systems containing piroxicam and hydroxypropyl-¦Â -cyclodextrin prepared by various processes, were characterized by FTIR, thermal stability, photo stability and dissolution studies. Hydroxypropyl-¦Â -cyclodextrin enhanced the solubility of piroxicam and increased dissolution rates from the binary systems. The complex prepared by co-evaporation method was found to yield better dissolution rate and stability as characterized in present study over those of the complex prepared by other methods.
%U http://www.ijpsonline.com/article.asp?issn=0250-474X;year=2007;volume=69;issue=2;spage=323;epage=326;aulast=Doijad