%0 Journal Article
%T Estrogen receptor alpha gene polymorphisms and risk of HBV-related acute liver failure in the Chinese population
%A Zehui Yan
%A Wenting Tan
%A Yunjie Dan
%A Wenli Zhao
%A Chunqing Deng
%A Yuming Wang
%A Guohong Deng
%J BMC Medical Genetics
%D 2012
%I BioMed Central
%R 10.1186/1471-2350-13-49
%X A total of 1216 unrelated Han Chinese HBV carriers were recruited in this hospital-based case¨Ccontrol study, including 359 HBV surface antigen (HBsAg) carriers affected with ALF and 857 asymptomatic HBsAg carriers. Two ESR1 haplotype tagging polymorphisms, c.30£¿T£¿>£¿C (rs2077647) and c.453-397£¿T£¿>£¿C (rs2234693), were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.We observed a significantly increased susceptibility to HBV-ALF associated with the c.30£¿C allele (P£¿=£¿8.65£¿¡Á£¿10-4), c.453-397£¿C allele (5.37£¿¡Á£¿10-4) and [c.30£¿C; c.453-397£¿C] haplotype (Dominant model, P =0.0004, odds ratio£¿=£¿1.53, 95% CI 1.23£¿~£¿1.96) compared with the T alleles and [c.30£¿T; c.453-397£¿T] haplotype of c.30£¿T£¿>£¿C and c.453-397£¿T£¿>£¿C polymorphisms, respectively.Our study suggests that [c.30£¿C; c.453-397£¿C] hapotype may be a risk factor for genetic susceptibility to HBV-related ALF in the Chinese population. It also emphasizes the importance of ESR1 in the pathophysiology of HBV-related ALF on the population level.
%U http://www.biomedcentral.com/1471-2350/13/49/abstract