%0 Journal Article
%T No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations
%A Hiromi Sawai
%A Nao Nishida
%A Hamdi Mbarek
%A Koichi Matsuda
%A Yoriko Mawatari
%A Megumi Yamaoka
%A Shuhei Hige
%A Jong-Hon Kang
%A Koichi Abe
%A Satoshi Mochida
%A Masaaki Watanabe
%A Masayuki Kurosaki
%A Yasuhiro Asahina
%A Namiki Izumi
%A Masao Honda
%A Shuichi Kaneko
%A Eiji Tanaka
%A Kentaro Matsuura
%A Yoshito Itoh
%A Eiji Mita
%A Masaaki Korenaga
%A Keisuke Hino
%A Yoshikazu Murawaki
%A Yoichi Hiasa
%A Tatsuya Ide
%A Kiyoaki Ito
%A Masaya Sugiyama
%A Sang Hoon Ahn
%A Kwang-Hyub Han
%A Jun Yong Park
%A Man-Fung Yuen
%A Yusuke Nakamura
%A Yasuhito Tanaka
%A Masashi Mizokami
%A Katsushi Tokunaga
%J BMC Medical Genetics
%D 2012
%I BioMed Central
%R 10.1186/1471-2350-13-47
%X We did not detect any associations between rs17401966 and HCC in the Japanese cohorts (replication 1: OR£¿=£¿1.09, 95£¿% CI£¿=£¿0.82-1.43; replication 2: OR£¿=£¿0.79, 95£¿% CI£¿=£¿0.54-1.15), in the Korean cohort (replication 3: OR£¿=£¿0.95, 95£¿% CI£¿=£¿0.66-1.36), or in the Hong Kong Chinese cohort (replication 4: OR£¿=£¿1.17, 95£¿% CI£¿=£¿0.79-1.75). Meta-analysis using these cohorts also did not show any associations with P£¿=£¿0.97.None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC. This may be due to differences in the genetic diversity among the Japanese, Korean and Chinese populations. Other reasons could be the high complexity of multivariate interactions between the genomic information and the phenotype that is manifesting. A much wider range of investigations is needed in order to elucidate the differences in HCC susceptibility among these Asian populations.
%K Hepatitis B
%K hepatocellular carcinoma
%K candidate SNP
%K replication study
%K genome-wide association study
%U http://www.biomedcentral.com/1471-2350/13/47/abstract